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Usually I’m pretty rigid about getting my taxes done early, but for some reason this year I’ve been taking a particularly long time to just sitting down and doing them. There’s actually been several times over the last 2 months that I’ve been at , , , etc and I’ve picked up the box for , just put it back on the shelf. Not sure why exactly – probably cause I think I’m going to owe this year.
While driving home yesterday, I finally caved and decided to just stop off at and pick it up. As I pulled through the parking lot, which was surprisingly barren, it hit me that I could just go online to , rather than buying the physical CD. Why on earth would I want to walk inside, pick up the media, go home, install it and in 3-4 weeks toss the whole package into the trash? I promptly left Costco empty handed and headed home.
Then last night, I just jumped over to the web site, paid for the software and did a quick 50mb download. purchase viagra. The whole thing took under 2 minutes and I was up and running.
Just as , buying physical media for software is so 90′s. Then again, buying physical media for anything is so 90′s.
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So it goes.
P.S. I’m almost getting there with books too – everything should just be a PDF.
Sorry, the comment form is closed at this time.
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Has different non–PDE-5 cross-inhibitions than vardenafil or sildenafil; more potent in inhibiting PDE-11, which is found in the pituitary, liver, testes, and heart; clinical consequences of this activity unknown at present
NexMed, Inc. (Nasdaq: NEXM), a specialty CRO and a developer of products based on the NexACT® technology, announced today that it received a Notice of Non-Compliance ("Notice") as part of the review process from Health Canada for its New Drug Submission ("NDS") for the Vitaros erectile dysfunction treatment filed in February 2008. The deficiencies cited related to the product's CMC (Chemistry, Manufacturing and Controls). There were no pre-clinical or clinical deficiencies cited in the Notice. The Notice is a routine end-of-review communication from Health Canada when additional information is needed to reach final decision on product approval.
Intermittent dosing: 10 mg PO before sexual activity; may increase to 20 mg maximum or decrease to 5 mg based on efficacy and adverse effects; not to exceed 1 dose/d
Metabolism (breakdown) of sildenafil is slowed by aging, liver and kidney dysfunction, and concurrent use of certain medications (such as erythromycin--an antibiotic, and protease inhibitors, for HIV). Slowed breakdown allows sildenafil to accumulate in the body and potentially may increase the risk of side effects. Therefore in men over 65, in men with substantial kidney and liver disease, and in men who also are taking protease inhibitors, the doctor will initiate sildenafil at a lower dose (25 mg) to avoid accumulation of sildenafil in the body. A protease inhibitor ritonavir (Norvir) is especially potent in increasing the accumulation of sildenafil, thus men who are taking Norvir should not take sildenafil doses higher than 25 mg and at a frequency of no greater than once in 48 hours.
"We were able to show the tissue was able to integrate and function in the long term, which means we can start planning clinical applications [in humans]," said Dr. Anthony Atala, director of the Institute for Regenerative Medicine at Wake Forest University Baptist Medical Center and senior author of the study. "Our hope is to be able to treat patients with many conditions, including congenital abnormalities of the penis, traumatic injuries, penile cancer and severe cases of erectile dysfunction that don't benefit from drug treatments."
Sildenafil is available in 3 doses: 25 mg, 50 mg, and 100 mg. The starting dose depends on the clinical situation. A man in his fifth decade of life with mild sexual dysfunction that is probably related to psychological factors can start on the 25-mg dose. Men with moderate-to-severe ED can begin at the 50-mg dose, and, after testing the effect of the drug on at least 3 occasions (although 5-6 tries is recommended), the dose can be modified. Men with severe ED can start on the 100-mg dose; these men are not likely to achieve a satisfactory response, but they should make 3-4 attempts before starting another form of therapy.
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The history should include the frequency and duration of symptoms, the presence or absence of morning erections and the quality of the relationship with the sexual partner. The sudden onset of erectile dysfunction in association with normal morning erections or a poor relationship suggests psychogenic impotence.4
Adverse effects, including headache, dizziness, and stomach upset
ED can affect intimate relationships and cause low self-esteem in men, as well as in their sexual partners. Smoking, alcohol abuse, and psychological factors, such as depression, stress, and anxiety, may increase the risk for erectile dysfunction. Common treatments for impotence include oral medications (e.g., sildenafil [Viagra®], tadalafil [Cialis®], vardenafil [Levitra®]), sex therapy, self-injections, vacuum devices, and in some cases, surgery.
Return to top Is premature ejaculation a sign of a serious health problem?
Vitamin E – Take 400 IUs daily.
Study in China is likely to bring further scrutiny of the common chemical
The risk of developing heart attacks or abnormal heart rhythms during sex is low in men with well controlled hypertension, mild disease of the heart's valves, well controlled heart failure, mild and stable angina (with a favorable treadmill stress test), successful coronary stenting or bypass surgery, and a remote history of heart attack (more than 8 weeks previously). Sildenafil can be used safely in men in these low risk groups.
Note: Clinical practice guidelines are “guides” only and may not apply to all patients and all clinical situations. Thus, they are not intended to override clinicians' judgment. All ACP clinical practice guidelines are considered automatically withdrawn or invalid 5 years after publication, or once an update has been issued.
Erectile dysfunction. This penile tumescence monitor is placed at the base and near the corona of the penis. It is connected to a monitor that records a continuous graph depicting the force and duration of erections that occur during sleep. The monitor is strapped to the leg. The nocturnal penile tumescence test is conducted on several nights to obtain an accurate indication of erections that normally occur during the alpha phase of sleep.
Alcohol and Erectile Dysfunction
Help reduce stress, tension, anxiety and depression.
Curb your vices. If scientific evidence and public service announcements haven't convinced you to stop smoking or abusing drugs, maybe a desire to avoid erectile dysfunction will.
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